Study type: Medical/biological study (experimental study)

Effects of 25 mT static magnetic field on blood pressure in reserpine-induced hypotensive Wistar-Kyoto rats. med./bio.

Published in: Bioelectromagnetics 2005; 26 (1): 36-48

Aim of study (acc. to author)

To investigate the effects of a static magnetic fileds of 10 and 25mT on several cardiovascular parameters in reserpin-induced hypotensive rats.

Background/further details

A total of 60 animals were divided into 6 experimental groups; either non-exposed or exposed to a static magnetic field of 10 mT and 25 mT, respectively. Animals were treated similarly with saline injection or alernatively with reserpine (5 mg/kg). During a 12 week magnetic field exposure effects on the cardiovascular system were determined: e.g. blood pressure, heart rate, blood level of vasoacitve substances, and behavioural changes.

Endpoint

Exposure

Exposure Parameters
Exposure 1:
Exposure duration: continuous for 12 weeks
Exposure 2:
Exposure duration: continuous for 12 weeks

Exposure 1

Main characteristics
Frequency
Type
Exposure duration continuous for 12 weeks
Additional info Animals were divided into 6 group (n=10 each): Group 1: no exposure with intraperitoneal (ip) saline injection, group 2: 10 mT exposure with ip saline injection, group 3: 25 mT with ip saline injection, group 4: no exposure with ip reserpine (RES) injection, group 5: 10 mT with ip RES injection and group 6: 25 mT with ip RES injection
Exposure setup
Exposure source
Chamber Acrylic cage/ 40 x 24 x 20 cm³ lwh
Setup Plates were attached to both outer walls of the cage which was designated as (x,y,z) = (0,0,0) and the animal's head position was in the range of (x,y,z) = (±19 cm,±8 cm, ±12 cm)
Additional info The minimum distance between the inside magnetic plates was 26 cm.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 3 mT minimum measured - up to 10 mT

Exposure 2

Main characteristics
Frequency
Type
Exposure duration continuous for 12 weeks
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 7.5 mT minimum measured - up to 25 mT

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

It was found that the 25 mT magnetic field, but not the 10 mT field, significantly reversed the reserpine-induced effects such as reduced blood pressure, and altered FOB parameters.

Study character:

Study funded by