Study type: Medical/biological study (experimental study)

Human fetal lung fibroblasts: in vitro study of repetitive magnetic field exposure at 0.2, 1.0, and 1.5 T med./bio.

By: Wiskirchen J, Gronewaller EF, Heinzelmann F, Kehlbach R, Rodegerdts E, Wittau M, Rodemann HP, Claussen CD, Duda SH
Published in: Radiology 2000; 215 (3): 858-862
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Aim of study (acc. to author)

To study whether repetitive exposure to magnetic fields of three magnetic resonance imaging units (0.2, 1.0, and 1.5 Tesla) affects the growth of human fetal lung fibroblasts.

Endpoint

Exposure

Exposure Parameters
Exposure 1:
Exposure duration: continuous for 1 h/day for 5 consecutive days
Exposure 2:
Exposure duration: continuous for 1 h/day for 5 consecutive days
Exposure 3:
Exposure duration: continuous for 1 h/day for 5 consecutive days

Exposure 1

Main characteristics
Frequency
Exposure duration continuous for 1 h/day for 5 consecutive days
Exposure setup
Exposure source
  • MR unit
Chamber Plexiglas exposure chambers. They were connected to a warm-water cycle to keep the temperature constant in the range of 36.5°C to 37.5°C.
Setup The cells were placed into the chamber that was positioned in the center of the magnetic field of the MR imaging unit. The control groups were placed into a second chamber that was positioned outside the magnetic field in the control room.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 0.2 T - - - -

Exposure 2

Main characteristics
Frequency
Exposure duration continuous for 1 h/day for 5 consecutive days
Exposure setup
Exposure source
Setup The cells were positioned in the magnetic bore of a 1.0 T MR imaging unit.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1 T - - - -

Exposure 3

Main characteristics
Frequency
Exposure duration continuous for 1 h/day for 5 consecutive days
Exposure setup
Exposure source
Setup The cells were positioned in the magnetic bore of a 1.5 T MR imaging unit.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1.5 T - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Cell cycle analysis did not show statistically significant differences between the exposed and control cells. The population doublings did not indicate any growth modulation during irradiation. Proliferation kinetics did not provide any hint of midterm growth modulation effects of irradiation.
Repetitive magnetic field exposure does not exert any growth-modulating effect on overall cell growth and cell cycle distribution of cultured human fetal lung fibroblasts. Midterm effects of magnetic field exposure were not found.

Study character:

Study funded by

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