Study type: Medical/biological study (experimental study)

Extremely low frequency magnetic field induces hyperalgesia in mice modulated by nitric oxide synthesis. med./bio.

Published in: Life Sci 2006; 78 (13): 1407-1412

Aim of study (acc. to author)

To study the effect of extremely low frequency magnetic field on hyperalgesia in mice.

Background/further details

The possible nitric oxide (NO) system associated with the hyperalgesic effects of the exposure of extremely low frequency magnetic fields was considered. The involvement of calcium-dependent NO pathway in hyperalgesia was evaluated by blocking Ca2+ sources with NMDA receptor antagonist (MK-801) and calcium channel blocker (nimodipine).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: continuous for 48 h

Exposure 1

Main characteristics
Frequency 60 Hz
Type
Waveform
  • unspecified
Exposure duration continuous for 48 h
Exposure setup
Exposure source
Setup coils produced a magnetic field in the vertical direction at the center of the system with the cage located between the coil pair. Sham exposed mice were placed in the same location with the coils switched off.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 2 mT effective value unspecified - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The exposure of animals to extremely low frequency magnetic field lowered pain threshold and elevated NO synthesis in brain and spinal cord.The hyperalgesic effects of extremely low frequency magnetic field were shown to be associated with calcium-dependent nitric oxide synthase.The expression of calcium-dependent constitutive nitric oxide synthases and calcium-independent inducibel nitric oxide synthases were not changed by extremely low frequency magnetic fields.
The authors suggest that extremely low frequency magnetic field produce hyperalgesia by modulating NO synthesis via Ca2+-dependent nitric oxide synthase.

Study character:

Study funded by

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