Study type: Medical/biological study (experimental study)

Exposure to 60 Hz magnetic fields does not alter clinical progression of LGL leukemia in Fischer rats. med./bio.

Published in: Carcinogenesis 1996; 17 (12): 2681-2687

Aim of study (acc. to author)

To determine if 60 Hz magnetic field can alter the clinical progression of leukemia in rats.

Background/further details

The LGL (large granular lymphocytic) leukemia model was used in this study to induce leukemia in young, male rats within a relatively short period of time by engrafting spleen cells from aged leukemic rats.
A total of 72 animal (divided into 4 groups/18 animals each) were used in this study.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: 20 h/day, 7 days/week for up to 10 weeks

General information

animals were treated in four groups: i) exposure to 1 mT magnetic field ii) no exposure to magnetic field iii) exposure to 0.1 µT magnetic field (ambient control) iv) 5 Gy whole body irradiation from Cobalt-60 4 days before start of exposure to EMF

Exposure 1

Main characteristics
Frequency 60 Hz
Type
Waveform
Polarization
Exposure duration 20 h/day, 7 days/week for up to 10 weeks
Exposure setup
Exposure source
Setup six 10.5 x 3.6 m electrodes, 30 cm apart, arranged vertically, sourrounded by rectangular 1.07 x 4 m coils
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1 mT - measured - -

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The clinical progression of LGL leukemia in rats was not significantly altered by a 10 G magnetic field exposure.

Study character:

Study funded by

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