Study type: Medical/biological study (experimental study)

Clinical progression of transplanted large granular lymphocytic leukemia in Fischer 344 rats exposed to 60 Hz magnetic fields med./bio.

By: Morris JE, Sasser LB, Miller DL, Dagle GE, Rafferty CN, Ebi KL, Anderson LE
Published in: Bioelectromagnetics 1999; 20 (1): 48-56
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Aim of study (acc. to author)

To determine if 60 Hz magnetic field can alter the clinical progression of leukemia in rats.

Background/further details

The LGL (large granular lymphocytic) leukemia model was used in this study to induce leukemia in young, male rats within a relatively short period of time by engrafting spleen cells from aged leukemic rats.
A total of 432 animal (divided into 4 groups, 108 animals each) were used in this study.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: 20 h/day, 7 days/week for up to 11 weeks

General information

Animals were treated in 4 groups: i) EMF exposure ii) sham exposure iii) ambient control (< 0.1 µT) iv) positive control : 5 Gy whole body exposure to 60Co4 four days before start of EMF exposure

Exposure 1

Main characteristics
Frequency 60 Hz
Type
Waveform
Polarization
Exposure duration 20 h/day, 7 days/week for up to 11 weeks
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1 mT - measured - -

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The applied magnetic field did not significantly alter the clinical progression of LGL leukemia in rats.

Study character:

Study funded by

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