Study type: Medical/biological study (experimental study)

Magnetosensory function in rats: localization using positron emission tomography med./bio.

Published in: Synapse 2009; 63 (5): 421-428

Aim of study (acc. to author)

To show that electromagnetic fields produce magnetosensory evoked potentials in rats and to localize the activated region in the brain.

Background/further details

The authors wanted to extend results from previous studies on magnetosensory evoked potentials in humans (publication 15027) and rabbits (publication 9242).
In the first experiment, 10 female rats were exposed to a magnetic field. In a second experiment, the effect of the magnetic field on the regional rate of glucose uptake was analyzed in another group of 10 rats using PET. Each rat was scanned twice: after field exposure and after sham exposure.



Exposure Parameters
Exposure 1: 60 Hz
Modulation type: pulsed
Exposure duration: 45 min

Exposure 1

Main characteristics
Frequency 60 Hz
Exposure duration 45 min
Modulation type pulsed
Pulse width 2 s
Additional info

interstimulus period = 5 s

Exposure setup
Exposure source
Setup rats placed in 28 cm x 18 cm x 13 cm non-metallic cages inside the coil
Sham exposure A sham exposure was conducted.
Measurand Value Type Method Mass Remarks
magnetic flux density 0.25 mT - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure

Main outcome of study (acc. to author)

Onset magnetosensory evoked potentials were detected in all 10 rats, and offset magnetosensory evoked potentials were detected in 7 of the 10 rats.The magnetosensory evoked potentials were similar in magnitude, latency and dynamical origin to those exhibited by rabbits (see publication 9242) and humans (see publication 15027). Exposure to the magnetic field stimulated cerebellar uptake of fluorodeoxyglucose compared to the sham exposure in the same animals. The activated region was located in the posterior central cerebellum.
The results indicated that magnetosensory evoked potentials in rats were associated with increased glucose utilization in the cerebellum, thereby supporting earlier evidence that electromagnetic field transduction occurred in the brain.

Study character:

Study funded by

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