Medical/biological study (experimental study)

Magnetosensory function in rats: localization using positron emission tomography.

Published in: Synapse 2009; 63 (5): 421-428

Aim of study (acc. to author)

To show that electromagnetic fields produce magnetosensory evoked potentials in rats and to localize the activated region in the brain.
Background/further details: The authors wanted to extend results from previous studies on magnetosensory evoked potentials in humans (publication 15027) and rabbits (publication 9242).
In the first experiment, 10 female rats were exposed to a magnetic field. In a second experiment, the effect of the magnetic field on the regional rate of glucose uptake was analyzed in another group of 10 rats using PET. Each rat was scanned twice: after field exposure and after sham exposure.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: 45 min
Exposure 1
Main characteristics
Frequency 60 Hz
Type
Exposure duration 45 min
Exposure setup
Exposure source/structure
Setup details rats placed in 28 cm x 18 cm x 13 cm non-metallic cages inside the coil
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Remarks
magnetic flux density 0.25 mT - - -
Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated material:
Investigated organ system:
Time of investigation:
  • during exposure

Main outcome of study (acc. to author)

Onset magnetosensory evoked potentials were detected in all 10 rats, and offset magnetosensory evoked potentials were detected in 7 of the 10 rats.The magnetosensory evoked potentials were similar in magnitude, latency and dynamical origin to those exhibited by rabbits (see publication 9242) and humans (see publication 15027). Exposure to the magnetic field stimulated cerebellar uptake of fluorodeoxyglucose compared to the sham exposure in the same animals. The activated region was located in the posterior central cerebellum.
The results indicated that magnetosensory evoked potentials in rats were associated with increased glucose utilization in the cerebellum, thereby supporting earlier evidence that electromagnetic field transduction occurred in the brain.
Study character:

Study funded by

  • not stated/no funding

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