Study type: Medical/biological study (experimental study)

Effects of 50 Hz electromagnetic fields on rat cortical synaptosomes. med./bio.

Published in: Toxicol Ind Health 2009; 25 (4-5): 249-252

Aim of study (acc. to author)

To study the effect of electromagnetic field exposure on the physiological behaviour of rat cortical synaptosomes by evaluating modifications of synaptosomal mitochondrial respiration rate, ATP production, membrane potential, intra-synaptosomal mitochondrial Ca2+ concentration and free iron and isoprostane release.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Modulation type: pulsed
Exposure duration: continuous for 2 h

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
  • rectangular
Exposure duration continuous for 2 h
Modulation
Modulation type pulsed
Exposure setup
Exposure source
Setup culture dishes placed inside the rectangular solenoid, constructed with 2500 turns
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 2 mT peak value - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The extremely low frequency magnetic field exposure did not affect the physiological behaviour of cortical synaptosomes: Oxygen consumption remained unvaried in exposed synaptosomes; ATP production was also unchanged. The intra-synaptosomal mitochondrial Ca2+ concentration decreased slowly and there was a slight, but non-significant depolarisation of the synaptosomal membrane potential. The free iron and F2-isoprostane release remained unchanged after exposure.

Study character:

Study funded by

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