To study the effect of electromagnetic field exposure on the physiological behaviour of rat cortical synaptosomes by evaluating modifications of synaptosomal mitochondrial respiration rate, ATP production, membrane potential, intra-synaptosomal mitochondrial Ca2+ concentration and free iron release.
|Exposure duration||2 h|
|Rise time||2.7 ms|
|Fall time||2.4 ms|
|magnetic flux density||2 mT||peak value||measured||-||-|
The extremely low frequency magnetic field exposure did not affect the physiological behaviour of cortical synaptosomes: Oxygen consumption remained unvaried in exposed synaptosomes; ATP production was also unchanged. The intra-synaptosomal mitochondrial Ca2+ concentration decreased slowly and there was a slight, but non-significant depolarisation of the synaptosomal membrane potential. The free iron release remained unchanged after exposure.