Study type: Medical/biological study (experimental study)

Synaptosome behaviour is unaffected by weak pulsed electromagnetic fields med./bio.

Published in: Bioelectromagnetics 2007; 28 (6): 477-483

Aim of study (acc. to author)

To study the effect of electromagnetic field exposure on the physiological behaviour of rat cortical synaptosomes by evaluating modifications of synaptosomal mitochondrial respiration rate, ATP production, membrane potential, intra-synaptosomal mitochondrial Ca2+ concentration and free iron release.

Background/further details

12 experiments with synaptosomes of 12 male Sprague-Dawley rats were performed.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Modulation type: pulsed
Exposure duration: 2 h

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration 2 h
Modulation
Modulation type pulsed
Rise time 2.7 ms
Fall time 2.4 ms
Exposure setup
Exposure source
Setup rectangular solenoid consisting of a coil with 2500 turns
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 2 mT peak value measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The extremely low frequency magnetic field exposure did not affect the physiological behaviour of cortical synaptosomes: Oxygen consumption remained unvaried in exposed synaptosomes; ATP production was also unchanged. The intra-synaptosomal mitochondrial Ca2+ concentration decreased slowly and there was a slight, but non-significant depolarisation of the synaptosomal membrane potential. The free iron release remained unchanged after exposure.

Study character:

Study funded by

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