A novel hyperthermia-induction system was utilized and characterized. Heating was induced by 915 MHz continuous wave microwave irradiation. The response of two pancreatic cancer cell lines to hyperthermia was studied. Microwave-induced temperatures were 37, 41.5, 42.5, 43.5, or 44.5°C.
|Exposure duration||continuous for 1 h|
No significant difference was revealed between 37°C waterbath and 37°C microwave controls. Significant differences in the thermosensitivity of the two cell lines were found, with the most drug-sensitive cell line (PD PaCa) showing the greatest thermosensitivity. However, hyperthermia alone was not very effective as a single cytotoxic modality in either cancer cell line. The microwave-hyperthermia-induction system provided precise, automated temperature control, and ease of utilization and data management.