Study type: Technical/dosimetric study (experimental study)

Experimental method for the hyperthermic treatment of cells in tissue culture: initial application to pancreatic cancer cells tech./dosim.

By: Chang BK, Joines WT, Gregory JA
Published in: Bioelectromagnetics 1987; 8 (2): 195-202
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Aim of study (acc. to author)

A novel hyperthermia-induction system was utilized and characterized. Heating was induced by 915 MHz continuous wave microwave irradiation. The response of two pancreatic cancer cell lines to hyperthermia was studied. Microwave-induced temperatures were 37, 41.5, 42.5, 43.5, or 44.5°C.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 915 MHz
Modulation type: CW
Exposure duration: continuous for 1 h
  • SAR: 132 W/kg

Exposure 1

Main characteristics
Frequency 915 MHz
Type
Exposure duration continuous for 1 h
Modulation
Modulation type CW
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 132 W/kg - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

No significant difference was revealed between 37°C waterbath and 37°C microwave controls. Significant differences in the thermosensitivity of the two cell lines were found, with the most drug-sensitive cell line (PD PaCa) showing the greatest thermosensitivity. However, hyperthermia alone was not very effective as a single cytotoxic modality in either cancer cell line. The microwave-hyperthermia-induction system provided precise, automated temperature control, and ease of utilization and data management.

Study character:

Study funded by