To investigate whether magnetic field exposure has any copromoting effect in the skin tumor SENCAR mouse model.
Mice were treated with a single DMBA dose (2.56 µg, dermal application as an initiator) to initiate skin tumor development. First TPA application (2 µg, as a positive control for skin tumour promoting activity) was done 8 day later and than twice weekly accompanied by magnetic field exposure. The 50 Hz magnetic field exposure had a flux density of 50 µT and 0.5 mT either continuous or intermittent. TPA application and magnetic field exposure were continued for 26 and 105 weeks, respectively.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
50 Hz
Exposure duration:
repeated daily exposure, 21 h/day for 104 weeks
|
|
|
Exposure 2:
50 Hz
Exposure duration:
intermittent, 15 s On/Off, 21 h/day for 104 weeks
|
|
| Frequency | 50 Hz |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | repeated daily exposure, 21 h/day for 104 weeks |
| Exposure source |
|
|---|
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 500 µT | effective value | measured | - | - |
| magnetic flux density | 50 µT | effective value | measured | - | - |
| Frequency | 50 Hz |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | intermittent, 15 s On/Off, 21 h/day for 104 weeks |
| Exposure source |
|
|---|
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 500 µT | effective value | measured | - | - |
| magnetic flux density | 50 µT | effective value | measured | - | - |
No significant differences in survival time were found. magnetic field exposure, whether intermittent or continuous, did not seem to influence tehe epidermal thickness. Skin tumor occurrence was not altered by continuous magnetic field exposure as compared with sham control groups. Similar results were found for the intermittent exposed groups. However, a statistically significant difference was seen between the pooled continuous (i.e. 50 µT and 0.5 mT) and the pooled intermittent exposed groups.
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