The authors previously demonstrated that combined exposure to radiofrequency irradiation, which also induces hyperthermia and is teratogenic to exposed animals, and the industrial solvent, 2-methoxyethanol, produces enhanced teratogenicity in rats (see publication 3519).
The present study replicates and extends the previous research investigating the enhanced teratogenicity of combined radiofrequency irradiation and 2-methoxyethanol exposures. The interactive dose-related teratogenicity of radiofrequency irradiation was investigated by administering various combinations of radiofrequency irradiation and 2-methoxyethanol to groups of rats on gestation days 9 or 13; gestation day 20 fetuses were examined for malformations.
|Chamber||near field synthesizers enclosed within copper wire chambers housed in Forma 7010 or 74668 environmental chambers.|
|Setup||rats placed in cylinderical plexiglass holders with 12 mm holes|
|Additional info||Each rat was oriented in its long axis for induced EF to be parallel. Rats irradiated in one of the two RF-near field synthesizer facilities designed by NIOSH.|
The findings are consistent with and extend the previous research results. Synergism was found between radiofrequency irradiation and 2-methoxyethanol for some treatment combinations, but not for others. The study also clarified which gestational periods, radiofrequency irradiation durations, and 2-methoxyethanol doses would be most informative in future interaction studies to determine the lowest interactive effect level. Day 9 exposures generally evidenced little effect by 2-methoxyethanol, either by itself or in combination with radiofrequency irradiation. In contrast, day 13 exposures resulted in highly significant effects from 2-methoxyethanol and radiofrequency irradiation.