The authors previously demonstrated that combined exposure to radiofrequency irradiation and the industrial solvent 2-methoxyethanol produces enhanced teratogenicity in rats (see publication 3519). A subsequent study (see publication 3522) replicated and extended that research by investigating the interactive dose-related teratogenicity of radiofrequency irradiation and 2-methoxyethanol on gestation days 9 or 13.
The purpose of the present study is to determine the effects of radiofrequency irradiation (sufficient to maintain colonic temperatures at 42.0°C for 10 min) on a range of doses of 2-methoxyethanol (0, 20, 40, 60, 80, 100, 120 and 140 mg/kg) administered on gestation day 13 and to determine the lowest interactive effect level. Dams were sacrified on day 20.
Modulation type: CW
|Chamber||near field synthesizers enclosed within copper wire chambers housed in Forma 7010 or 74668 environmental chambers.|
|Setup||rats placed in cylinderical plexiglass holders with 12 mm holes|
|Additional info||Each rat was oriented in its long axis for induced electric field to be parallel. Rats irradiated in one of the two RF-near field synthesizer facilities designed by NIOSH.|
The findings are consistent with previous observations. Dose-related developmental toxicity was revealed for 2-methoxyethanol both in the presence and absence of radiofrequency irradiation. However, concurrent radiofrequency exposure changed the shape of the dose-effect curve of 2-methoxyethanol. These results indicate that combined exposure effects should be considered when developing exposure guidelines.