Study type: Medical/biological study (experimental study)

Growth modification of human colon adenocarcinoma cells exposed to a low-frequency electromagnetic field med./bio.

Published in: J Physiol Biochem 1999; 55 (2): 79-83

Aim of study (acc. to author)

The aim of this study was to investigate the influence of variable low-intensity, low-frequency electromagnetic fields on cultured human colon adenocarcinoma cells.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 1 Hz
Exposure duration: 15 min
Exposure 2: 1 Hz
Exposure duration: 15 min
rectangular
Exposure 3: 1 Hz
Exposure duration: 360 min
Exposure 4: 1 Hz
Exposure duration: 360 min
rectangular
Exposure 5: 25 Hz
Exposure duration: 15 min
Exposure 6: 25 Hz
Exposure duration: 15 min
reactangular
Exposure 7: 25 Hz
Exposure duration: 360 min
Exposure 8: 25 Hz
Exposure duration: 360 min
rectangular

Exposure 1

Main characteristics
Frequency 1 Hz
Type
Waveform
Exposure duration 15 min
Additional info sinusoidal
Exposure setup
Exposure source
Setup The solenoid was placed on the culture dish.
Additional info MF distribution was parallel to culture surface.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1.5 mT peak value unspecified - -
electric field strength 42 µV/m unspecified calculated - -
current density 63 µA/m² unspecified calculated - -

Exposure 2

Main characteristics
Frequency 1 Hz
Type
Waveform
  • rectangular
Exposure duration 15 min
Additional info rectangular
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1.5 mT peak value unspecified - -
electric field strength 42 µV/m unspecified calculated - -
current density 63 µA/m² unspecified calculated - -

Exposure 3

Main characteristics
Frequency 1 Hz
Type
Waveform
Exposure duration 360 min
Additional info sinusoidal
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1.5 mT peak value unspecified - -
electric field strength 42 µV/m unspecified calculated - -
current density 63 µA/m² unspecified calculated - -

Exposure 4

Main characteristics
Frequency 1 Hz
Type
Waveform
  • rectangular
Exposure duration 360 min
Additional info rectangular
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1.5 mT peak value unspecified - -
electric field strength 42 µV/m unspecified calculated - -
current density 63 µA/m² unspecified calculated - -

Exposure 5

Main characteristics
Frequency 25 Hz
Type
Waveform
Exposure duration 15 min
Additional info sinusoidal
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1.5 mT peak value unspecified - -
current density 1.59 mA/m² unspecified calculated - -
electric field strength 1.06 mV/m unspecified calculated - -

Exposure 6

Main characteristics
Frequency 25 Hz
Type
Waveform
  • rectangular
Exposure duration 15 min
Additional info reactangular
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1.5 mT peak value unspecified - -
current density 1.59 mA/m² unspecified calculated - -
electric field strength 1.06 mV/m unspecified calculated - -

Exposure 7

Main characteristics
Frequency 25 Hz
Type
Waveform
Exposure duration 360 min
Additional info sinusoidal
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1.5 mT peak value unspecified - -
current density 1.59 mA/m² unspecified calculated - -
electric field strength 1.06 mV/m unspecified calculated - -

Exposure 8

Main characteristics
Frequency 25 Hz
Type
Waveform
  • rectangular
Exposure duration 360 min
Additional info rectangular
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1.5 mT peak value unspecified - -
current density 1.59 mA/m² unspecified calculated - -
electric field strength 1.06 mV/m unspecified calculated - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

After exposure to the electromagnetic field for 15 minutes to 1 Hz and 25 Hz a statistically significant increase in cell growth was observed. Cultures exposed for 360 minutes to 1 Hz showed less cell growth as compared to their matching culture. No changes were noted for cultures exposed to 25 Hz for 360 minutes.

Study character:

Study funded by

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