Study type: Medical/biological study (experimental study)

Electrostimulation of macrophage NADPH oxidase by modulated high-frequency electromagnetic fields med./bio.

By: Gamaley I, Augsten K, Berg H
Published in: Bioelectrochem Bioenerg 1995; 38 (2): 415-418
Download citation in RIS format

Aim of study (acc. to author)

To investigate the possible activation of macrophage NADPH oxidase by electrostimulation.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 150 MHz
Modulation type: AM
Exposure duration: up to 60 min

Exposure 1

Main characteristics
Frequency 150 MHz
Type
Exposure duration up to 60 min
Modulation
Modulation type AM
Modulation frequency 15–99 Hz
Exposure setup
Exposure source
  • special designed coil, 17cm diameter; 15cm high
Setup sample in a flask (20 mm diameter) was placed in the center of the coil
Additional info Control sample was placed outside the coil.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 32.2 nT - - - 2.05 mW

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The NADPH oxidase could be activated by electrostimulation. This activation is non-linear time dependent, which must be assumed that this finding is caused by the inhibiton of the enzym by prolongated irradiation. Ca2+ in the media is promoting the enzyme activating process.

Study character:

Study funded by