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Medical/biological study (experimental study)

Microwave irradiation of rats at 2.45 GHz activates pinocytotic-like uptake of tracer by capillary endothelial cells of cerebral cortex.

Published in: Bioelectromagnetics 1990; 11 (4): 261-268

Aim of study (acc. to author)

Examination of effect of exposure in far-field to pulsed 2450 MHz radiation at 10 mW/cm² for periods from 10-120 minutes on blood-brain barrier in rats; analysis of mechanisms involved.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: pulsed
Exposure duration: 5 to 120 min
Exposure 1
Main characteristics
Frequency 2.45 GHz
Type
Charakteristic
Exposure duration 5 to 120 min
Modulation
Modulation type pulsed
Pulse width 10 µs
Repetition frequency 100 Hz
Exposure setup
Exposure source
Chamber Exposure chamber (1.2 x 1.2 x 1.2 m) lined with absorbing material.
Parameters
Measurand Value Type Method Mass Remarks
power density 10 mW/cm² mean measured - corresponding approximated SAR: 2 W/kg
power density 5 mW/cm² mean measured - corresponding approximated SAR: 1 W/kg
Measurement and calculation details
Forward and reflected powers were measured by bidirectional couplers (NARDA-30 V).
Reference articles
Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated material:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Exposure of rats to pulsed 2450 MHz radiation at 10 mW/cm² for periods from 10-120 minutes increased the uptake of an intravenously administered rhodamine-ferritin complex by the capillary endothelial of the rat brain.
Study character:

Study funded by

  • Food and Drug Administration (FDA), USA
  • National Institutes of Health (NIH), Maryland, USA
  • U.S. Navy

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