A pharmacological assay system was developed using a CNS agonist that produced a predictable behavioral response, and it was attempted to employ microwave radiation to alter the CNS availability of an antagonist that was normally excluded from the CNS. The report describes the influence of microwave radiation on the ability of a non-CNS-acting dopaminergic antagonist, domperidone, to block a drug effect of the dopaminergic agonist apomorphine.
|Chamber||styrofoam chamber 5 cm x 9 cm x 11cm hxwxl with 6mm diameter lucite rods|
|Setup||Conscious, unrestrained rats were placed individually into the chamber|
|Additional info||A seperate experiment was conducted in which mice were pretreated with 0.03 mg/kg of haloperidol and then exposed to MW(microwave) irradiation|
The results indicate that microwave irradiation can facilitate central effects of domperidone and one explanation for these findings is that microwave irradiation alters the permeability of the blood-brain barrier and increases the entry of domperidone to central sites of action.