Study type: Medical/biological study (experimental study)

Microwave facilitation of domperidone antagonism of apomorphine-induced stereotypic climbing in mice. med./bio.

Published in: Bioelectromagnetics 1987; 8 (1): 45-55

Aim of study (acc. to author)

A pharmacological assay system was developed using a CNS agonist that produced a predictable behavioral response, and it was attempted to employ microwave radiation to alter the CNS availability of an antagonist that was normally excluded from the CNS. The report describes the influence of microwave radiation on the ability of a non-CNS-acting dopaminergic antagonist, domperidone, to block a drug effect of the dopaminergic agonist apomorphine.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: CW
Exposure duration: continuous for 10 min

Exposure 1

Main characteristics
Frequency 2.45 GHz
Type
Waveform
Charakteristic
Exposure duration continuous for 10 min
Modulation
Modulation type CW
Exposure setup
Exposure source
Chamber styrofoam chamber 5 cm x 9 cm x 11cm hxwxl with 6mm diameter lucite rods
Setup Conscious, unrestrained rats were placed individually into the chamber
Additional info A seperate experiment was conducted in which mice were pretreated with 0.03 mg/kg of haloperidol and then exposed to MW(microwave) irradiation
Parameters
Measurand Value Type Method Mass Remarks
power density 200 W/m² unspecified measured - corresponding SAR: 45.5 W/kg calculated by means of Dewar-Flask calorimetry technique

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The results indicate that microwave irradiation can facilitate central effects of domperidone and one explanation for these findings is that microwave irradiation alters the permeability of the blood-brain barrier and increases the entry of domperidone to central sites of action.

Study character:

Study funded by