Study type: Medical/biological study (experimental study)

Effects of microwave-induced hyperthermia on the blood-brain-barrier of the rat med./bio.

By: Sutton CH, Carroll FB
Published in: Radio Sci 1979; 14 (6S): 329-334
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Aim of study (acc. to author)

Determination of thermal tolerance of the rat brain by establishing temperature-threshold levels above which the blood-brain barrier to protein is disrupted.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: CW
Exposure duration: continuous 10, 15, 20, 30, 45, 60, 90, 120, and 180 min

Exposure 1

Main characteristics
Frequency 2.45 GHz
Type
Waveform
Charakteristic
  • guided field
Exposure duration continuous 10, 15, 20, 30, 45, 60, 90, 120, and 180 min
Modulation
Modulation type CW
Exposure setup
Exposure source
Distance between exposed object and exposure source 0.02 m
Chamber anechoic chamber lined with Eccosorb
Setup A collar of Eccosorb was placed over the neck to shield the remainder of the animals body from mircowave radiation.
Parameters
Measurand Value Type Method Mass Remarks
power 10 W minimum measured - -
power 20 W - measured - -
power 80 W maximum measured - -
Additional parameter details

power was regulated so that brain temperature was kept at 40, 42, or 45 °C

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

Intense microwave-induced hyperthermia can increase the permeability of the blood-brain barrier. The tolerance of the blood-brain barrier is dose related (temperature, length of time) and the integrity of the blood-brain barrier is protected by body-core hypothermia at 30°C.

Study character: