To study the impact of transcranial pulsed magnetic stimulation on blood-brain barrier permeability in rats.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
Modulation type:
pulsed
Exposure duration:
one magnetic stimulation every 4 s for 10 min ( a total of 50 to 60 stimulations)
|
|
|
Exposure 2:
Modulation type:
pulsed
Exposure duration:
50 stimulation for 10 min a day for a week
|
|
Transcranial stimulation of the rat
| Frequency | |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | one magnetic stimulation every 4 s for 10 min ( a total of 50 to 60 stimulations) |
| Modulation type | pulsed |
|---|---|
| Rise time | 160 µs |
| Additional info |
slow repetition rate due to capacitor bank. |
| Exposure source | |
|---|---|
| Distance between exposed object and exposure source | 0.01 m |
| Setup | The coil was placed ventrally on the cranium of the anesthetized rats who were placed in Plexiglas tubes |
| Additional info | The coil skin distance did not exceed 1 cm. Limiting factor for exposure period is the heating-up of the capacitor bank. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 1.9 T | peak value | measured | - | - |
| Frequency | |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | 50 stimulation for 10 min a day for a week |
| Modulation type | pulsed |
|---|---|
| Rise time | 160 µs |
| Additional info |
slow repetition rate due to capacitor bank. |
| Exposure source | |
|---|---|
| Distance between exposed object and exposure source | 0.01 m |
| Setup | Anesthetized rats were placed in narrow Plexiglas tubes with coil be applied directly to the head. |
| Additional info | During stimulation the distance from the coil center to the part overlaying the head was 3 cm |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 1.9 T | peak value | measured | - | - |
No statistically significant differences in permeability surface-area product were found between the three groups for any of the three tracers (no effect of transcranial pulsed magnetic stimulation on blood-brain barrier permeability to [3H]sucrose, [14C]urea, and 36Cl-).
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