Study type: Medical/biological study (experimental study)

No effect of pulsed magnetic stimulation on the blood-brain barrier in rats. med./bio.

Published in: Neuroscience 1990; 38 (1): 277-280

Aim of study (acc. to author)

To study the impact of transcranial pulsed magnetic stimulation on blood-brain barrier permeability in rats.

Endpoint

Exposure

Exposure Parameters
Exposure 1:
Modulation type: pulsed
Exposure duration: one magnetic stimulation every 4 s for 10 min ( a total of 50 to 60 stimulations)
Exposure 2:
Modulation type: pulsed
Exposure duration: 50 stimulation for 10 min a day for a week

General information

Transcranial stimulation of the rat

Exposure 1

Main characteristics
Frequency
Type
Waveform
Exposure duration one magnetic stimulation every 4 s for 10 min ( a total of 50 to 60 stimulations)
Modulation
Modulation type pulsed
Rise time 160 µs
Additional info

slow repetition rate due to capacitor bank.

Exposure setup
Exposure source
Distance between exposed object and exposure source 0.01 m
Setup The coil was placed ventrally on the cranium of the anesthetized rats who were placed in Plexiglas tubes
Additional info The coil skin distance did not exceed 1 cm. Limiting factor for exposure period is the heating-up of the capacitor bank.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1.9 T peak value measured - -

Exposure 2

Main characteristics
Frequency
Type
Waveform
Exposure duration 50 stimulation for 10 min a day for a week
Modulation
Modulation type pulsed
Rise time 160 µs
Additional info

slow repetition rate due to capacitor bank.

Exposure setup
Exposure source
Distance between exposed object and exposure source 0.01 m
Setup Anesthetized rats were placed in narrow Plexiglas tubes with coil be applied directly to the head.
Additional info During stimulation the distance from the coil center to the part overlaying the head was 3 cm
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1.9 T peak value measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

No statistically significant differences in permeability surface-area product were found between the three groups for any of the three tracers (no effect of transcranial pulsed magnetic stimulation on blood-brain barrier permeability to [3H]sucrose, [14C]urea, and 36Cl-).

Study character:

Study funded by

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