Study type: Medical/biological study (experimental study)

Mitogen responsiveness after exposure of influenza virus-infected human mononuclear leukocytes to continuous or pulse-modulated radiofrequency radiation. med./bio.

Published in: Radiat Res 1987; 110 (3): 353-361

Aim of study (acc. to author)

To examine potential effects of radiofrequency exposure on functions of human mononuclear leukocytes which were previously exposed to a common pathogen, specifically influenza virus.

Background/further details

A standard measurement of immune responsiveness was used (mitogen-induced proliferation). Such a response is commonly depressed by in vivo influenza virus infection or by exposure of human leukocytes to the virus in vitro. Thus any synergistic or counteracting effect due to radiation might be accentuated and identified more readily than with radiation of previously unchallenged leukocytes.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: CW
Exposure duration: 4 h
  • SAR: 4 W/kg average over mass (cf. remarks) (4 mW/ml)
Exposure 2: 2.45 GHz
Modulation type: pulsed
Exposure duration: 4 h
-
Exposure 3: 2.45 GHz
Modulation type: pulsed
Exposure duration: 4 h
-

Exposure 1

Main characteristics
Frequency 2.45 GHz
Type
Waveform
Exposure duration 4 h
Modulation
Modulation type CW
Exposure setup
Exposure source
Chamber water-jacked CO2 incubator
Parameters
Measurand Value Type Method Mass Remarks
SAR 4 W/kg average over mass - cf. remarks 4 mW/ml

Exposure 2

Main characteristics
Frequency 2.45 GHz
Type
Waveform
Exposure duration 4 h
Modulation
Modulation type pulsed
Additional info

pulse modulation 16 Hz, duty cycle 1:2

Exposure setup
Exposure source
Chamber water-jacked CO2 incubator
Parameters

No parameters are specified for this exposure.

Exposure 3

Main characteristics
Frequency 2.45 GHz
Type
Waveform
Exposure duration 4 h
Modulation
Modulation type pulsed
Additional info

pulse modulation: 60 Hz, duty cycle 1:2.

Exposure setup
Exposure source
Chamber water-jacked CO2 incubator
Parameters

No parameters are specified for this exposure.

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The exposures produced no significant effects on leukocyte viability or on mitogen-stimulated DNA synthesis by either uninfected or influenza virus-infected leukocytes when compared to sham-exposed cells.

Study character:

Study funded by