Study type: Medical/biological study (experimental study)

Effects of 50 Hz magnetic fields on cancer induced by ionizing radiation in mice med./bio.

By: Heikkinen P, Kosma VM, Huuskonen H, Komulainen H, Kumlin T, Penttila I, Vaananen A, Juutilainen J
Published in: Int J Radiat Biol 2001; 77 (4): 483-495
Download citation in RIS format

Aim of study (acc. to author)

To investigate the effects of magnetic field exposure on the development of cancer induced by ionizing radiation in femal mice.

Background/further details

Animals were exposed to ionizing radiation of a total body dose of 4 Gy (1.33 Gy three times at 1 week intervals) before magnetic field exposure.
50 Hz magnetic field exposure was conducted 24 h/day for 1.5 year with a magnetic flux density variation cyle of 1.26 µT, 12.6 µT, and 126 µT respectively, 20 min each.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuous, 24 h/day for 1.5 years

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Polarization
Exposure duration continuous, 24 h/day for 1.5 years
Additional info vertical MF
Exposure setup
Exposure source
  • five rectangular coils (1.4 x 1.2 m)
Chamber Plastic Macrolon III cages
Additional info The coils placed on a woodend rack, with the vertical distance of 0.26 m between the adjecent coils. The coil at the bottom and the top had 15 turns and three in the middle had 10 turns.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1.26 µT minimum measured - 12.6 µT, and 126 µT
magnetic flux density 90 nT unspecified measured unspecified Background MF
magnetic flux density 41 µT minimum measured - 54 µT; Geomagnetic flux density
Additional parameter details

Animals pretreated to ionizing radiation at a total body dose of 4 Gy delivered as three equal fractions of 1.33 Gy at 1 week intervals.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

The incidence of neoplasia in various organs was increased by Ionizing radiation.
The incidence of any primary neoplasms was not increased by MF-exposure. However, the incidence of basophilic liver foci were increased. The hypothesis of a tumor co-promoting capacity of magnetic fields could not be supported by the results of this study.

Study character:

Study funded by

Related articles