JNK mitogen-activated protein kinase

  • c-jun N-terminal kinase
  • JNK
German: JNK Mitogen aktivierte Proteinkinase
Japanese: JNK分裂促進因子活性化タンパク質キナーゼ

Enzymology. A subfamily of mitogen-activated protein kinases that plays an important role in signal transduction and regulates cell proliferation, cell differentiation, and apoptosis. They activate transcription factor AP-1 via the phosphorylation of c-Jun proteins. They are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock. They belong together with p38-MAPKs to the group of stress-activated protein kinases.

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