Study type: Medical/biological study (experimental study)

Progression of arteriovenous bypass restenosis in mice exposed to a 50 Hz magnetic field med./bio.

By: Henderson B, Tagwerker A, Mayrl C, Pfister G, Böck G, Ulmer H, Dietrich H, Wick G
Published in: Cell Stress Chaperones 2003; 8 (4): 373-380
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Aim of study (acc. to author)

To investigate the effects of a 700 µT, 50 Hz magnetic field exposure up to three weeks on development and progression of restenosis in mice.

Background/further details

A surgical venous bypass model was used in this study to mimic many of the properties of the human disease. Mice were allowed to recover post operatively for 6 days. A total of 70 mice were used for the magnetic field/sham exposure. Mice were exposed to a 700 µT/50 Hz magnetic field for one week (10 animals), two weeks (10 animals), or three weeks (15 animals). An equivalent number of animals were sham exposed.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: repeated daily exposure, 2 h/day, 5 days a week for 1, 2 or 3 weeks

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
  • unspecified
Exposure duration repeated daily exposure, 2 h/day, 5 days a week for 1, 2 or 3 weeks
Exposure setup
Exposure source
Setup animals were placed in a plastic cage completely covered by coils.
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 700 µT unspecified measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Mice exposed for one week showed significantly smaller neointima formation (which means that the epidermal thickness of the venous bypass was reduced) as compared with sham exposed animals, although this effect was not observed in animals exposed for a longer period of time. Mononuclear cell infiltration and expression of heat shock protein 60 were not found to be altered due to magnetic field exposure.

Study character:

Study funded by