Study type: Medical/biological study (experimental study)

Erythropoietic changes in rats after 2.45 GHz nonthermal irradiation med./bio.

Published in: Int J Hyg Environ Health 2004; 207 (6): 549-554

Aim of study (acc. to author)

To study the erythropoietic changes in rats subchronically exposed to radiofrequency microwave irradiation at nonthermal levels.



Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: CW
Exposure duration: repeated daily exposure, 2 h/day for 2, 8, 15 or 30 days

General information

The exposed group (n=40) was divided in 4 subgroups (each n=10) that were exposed 2, 8, 15 or 30 days. The unexposed group (n=24) serving as control was divided in 4 subgroups (n=6 each) to be sacrificed on experimental days 2, 8, 15 or 30

Exposure 1

Main characteristics
Frequency 2.45 GHz
Exposure duration repeated daily exposure, 2 h/day for 2, 8, 15 or 30 days
Additional info Reference article: World Health Organization (WHO): Electromagnetic fields (300 Hz to 300 GHz). In: Environmental Health Criteria 137. Geneva: World Health Organization 1993
Modulation type CW
Exposure setup
Exposure source
Distance between exposed object and exposure source 1.4 m
Setup The rats were placed in individual Plexiglas cages and were kept in a controlled environment at 22°C with 12 h ligh/dark.
Measurand Value Type Method Mass Remarks
power density 50 W/m² mean measured - to 100 W/m², corresponding to an approximate SAR 1-2 W/kg for middle sized rat

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • before exposure
  • after exposure

Main outcome of study (acc. to author)

In the exposed rats erythrocyte count, haemoglobin and hematocrit were increased in peripheral blood on irradiation days 8 and 15. Anuclear cells and erythropoietic cells were significantly decreased in the bone marrow on day 15, but micronucleated cells' frequency was increased.
Under these experimental conditions, microwave irradiation caused disturbance in red blood cell maturation and proliferation, and induced micronucleus formation in erythropoietic cells.

Study character:

Study funded by

Related articles