Study type: Medical/biological study (observational study)

Lack of effect of extremely low frequency electromagnetic fields on cyclin-dependent kinase 4 inhibitor gene p18(INK4C) in electric energy workers. med./bio.

Published in: Arch Med Res 2005; 36 (2): 120-123

Aim of study (acc. to author)

To study whether or not long-term extremely low frequency electromagnetic field exposure may be a risk factor for human cancer due to the gene p18INK4C deletion/mutation.

Background/further details

One mechanism through which extremely low frequency electromagnetic field could influence neoplastic development is the deletion/mutation of cancer-related genes. Cell proliferation follows an orderly progression through the cell cycle, which is governed by different cyclins and cyclin-dependent kinase inhibitors. The putative tumor suppressor gene p18INK4C encodes a specific inhibitor of cyclin D-cyclin-dependent kinase 4 inhibitor complexes having an important role in cell-cyclin regulation. It has been revealed to be deleted/mutated in a variety of human cancers.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50–60 Hz
Exposure duration: 8 h/day for past 10 to 20 years
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General information

Occupational exposure

Exposure 1

Main characteristics
Frequency 50–60 Hz
Type
Waveform
Exposure duration 8 h/day for past 10 to 20 years
Exposure setup
Exposure source
Setup The study subjects were electric workers working at a power substation. These subjects were living 200 m away from the substation.
Additional info Thje control subjects were non electric worker who were not residing close to a subtation.
Parameters

No parameters are specified for this exposure.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Compared to the controls, band migration of exon 1 was revealed to be indifferent in all the subjects tested. However, only exon 2 of two electric workers was slow in migration with respect to both control and other subjects. This slow migration indicates that point mutations or polymorphisms may exist in this region of the p18INK4C gene.
The data suggest that long-term extremely low frequency electromagnetic field exposure does not significantly increase the risk of cancer.

Study character:

Study funded by

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