One mechanism through which extremely low frequency electromagnetic field could influence neoplastic development is the deletion/mutation of cancer-related genes. Cell proliferation follows an orderly progression through the cell cycle, which is governed by different cyclins and cyclin-dependent kinase inhibitors. The putative tumor suppressor gene p18INK4C encodes a specific inhibitor of cyclin D-cyclin-dependent kinase 4 inhibitor complexes having an important role in cell-cyclin regulation. It has been revealed to be deleted/mutated in a variety of human cancers.
Exposure duration: 8 h/day for past 10 to 20 years
No parameters are specified for this exposure.
Compared to the controls, band migration of exon 1 was revealed to be indifferent in all the subjects tested. However, only exon 2 of two electric workers was slow in migration with respect to both control and other subjects. This slow migration indicates that point mutations or polymorphisms may exist in this region of the p18INK4C gene.
The data suggest that long-term extremely low frequency electromagnetic field exposure does not significantly increase the risk of cancer.