Study type: Medical/biological study (experimental study)

Extremely low frequency magnetic fields modulate bicuculline-induced-convulsion in rats. med./bio.

Published in: Arch Pharm Res 2005; 28 (5): 587-591

Aim of study (acc. to author)

To study whether magnetic fields exposure additionally contribute to the convulsion mediated by the benzodiazepine-GABA complex receptor.

Background/further details

The onset and duration of convulsions induced by bicuculline alone or by co-exposure to magnetic fields and bicuculline were investigated.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: continuous for 6 h

General information

Seven to ten rats were arranged in groups which were treated under the following conditions: i) sham exposure ii) exposure to magnetic field iii) sham exposure, treated with bicuculline methobromide iv) exposure to magnetic field, treated with bicuculline all drugs were administered after the MF exposure or in the sham

Exposure 1

Main characteristics
Frequency 60 Hz
Type
Waveform
Exposure duration continuous for 6 h
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 2 mT unspecified unspecified - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Magnetic fields strengthened the convulsion induced by bicuculline with a shortening of the onset time, but lengthening of the duration time. Co-exposure to magnetic fields and bicuculline decreased the GABA contents in the cortex, hippocampus and hypothalamus, whereas magnetic fields alone reduced the level of GABA only in the hippocampus.
These data indicate that the exposure to magnetic fields may modulate bicuculline-induced convulsions due to GABA neurotransmissions in rat brains.

Study character:

Study funded by

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