Study type: Medical/biological study (experimental study)

Electric field exposure alters serum melatonin but not pineal melatonin synthesis in male rats. med./bio.

Published in: Bioelectromagnetics 1994; 15 (5): 427-437

Aim of study (acc. to author)

To investigate the effects of a 30 day electric field exposure (60 Hz, 65 kV/m) on the circadian production and secretion of the pineal gland hormone melatonin in male rats.

Background/further details

Activities of two pineal gland enzymes (i.e. enzyme activity (pineal N-acetyltransferase and hydroxyindole-o-methyltransferase), both involved in the biosynthesis of melatonin, and pineal melatonin levels, and melatonin levels in bood serum were investigated during light and dark phase.



Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: continuous, 30 day; sham exposed 20 day

Exposure 1

Main characteristics
Frequency 60 Hz
Exposure duration continuous, 30 day; sham exposed 20 day
Exposure setup
Exposure source
  • three parallel plates, a top electrified plate and the intermediate and bottom plates grounded
Chamber two identical windowless rooms with 10 in x 4.75 in x 4.5 in Plexiglass cages
Setup the aminals; between the two top plates exposed and between the two bottom plates sham exposed
Additional info cages with wire mesh floors in contact with ground plate of the exposure apparatus. EF strength mapped with a 10 cm Kaune disk probe with a 2.48 cm diameter center
Measurand Value Type Method Mass Remarks
electric field strength 65 kV/m mean measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

Electric field exposure had no effect on pineal melatonin level or enzymatic activity of N-acetyltransferase and hydroxyindole-o-methyltransferase, respectively. However, exposed animals exhibited lower serum melatonin levels at night as compared with sham-exposed animals.
These findings suggest that degradation or tissue uptake of melatonin is stimulated due to exposure.

Study character:

Study funded by

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