To investigate the effects of low frequency electromagnetic fileds on mammary carcinoma in rat induced by N-nitrosomethylurea (NMU).
Rats were kept under normal light conditions (i.e. 12 h light/ 12 h dark) and were exposed either to static or to variable magnetic fields (MF). Exposure conditions were chosen 0.5 and 3 h per day, respectively for a time periode of 2 years. One part of the animals recived a single intravenously injection of 50 mg/kg of the chemical carcinogen NMU. None-NMU-treated and none-exposed animals served as control.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
50 Hz
Exposure duration:
0.5 or 3 h/day for 2 years
|
|
|
Exposure 2:
Exposure duration:
0.5 or 3 h/day for 2 years
|
| Frequency | 50 Hz |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | 0.5 or 3 h/day for 2 years |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic field strength | 16 A/m | effective value | unspecified | - | - |
| Frequency | |
|---|---|
| Type | |
| Exposure duration | 0.5 or 3 h/day for 2 years |
| Exposure source |
|
|---|
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic field strength | 16 A/m | effective value | unspecified | - | - |
Without prior administration of NMU, magnetic filed exposure lead only to a week development of mammary carcinomas. Incidence and latent period of mammary tumors depend on duration and kind of the magnetic field exposure. A 3 h exposure and exposure with variable magnetic field were more effective than a 0.5 h exposure and exposure with static magnetic fields, respectively. Beside prevailed mammary adenocarcinomas neoplasms were found occassionaly in kidneys, ovary, large intestine, uterus and thyroid gland.
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