Study type: Medical/biological study (experimental study)

Effect of 50 Hz sinusoidal electromagnetic field on the kinetics of 14CO2 exhalation after [14C]-N-nitrosodiethylamine administration in mice med./bio.

By: Singh S, Khanduja KL, Mittal PK
Published in: Bioelectromagnetics 1999; 20 (1): 1-4
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Aim of study (acc. to author)

This in vivo study was performed to examine the effects of 50 Hz sinusoidal electromagnetic field on carcinogen metabolism in mice.

Background/further details

The experiments were carried out with 12 male mice (six to seven week-old) which received intraperitoneal the radiolabelled carcinogen 14C-N-nitrosodiethlamine (NDEA). The endproduct of this carcinogen metabolism is 14CO2. Increased metabolic turnover of 14C-NDEA to 14CO2 indicated lower availability of reactive metabolites which are responsible for a tumor initiation.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Modulation type: CW
Exposure duration: 8 h/day, for 8 weeks

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration 8 h/day, for 8 weeks
Modulation
Modulation type CW
Exposure setup
Exposure source
Chamber plastic cages
Setup exposure field in NS direction
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 2 mT effective value - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • before exposure
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

There was a significant increase in the metabolic turnover of 14C-NDEA into 14CO2 at the end of both six and eight weeks of magnetic field exposure. The electromagnetic field might thereby provide protection from the carcinogenic effects of the carcinogen NDEA in mice.

Study character:

Study funded by

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