Study type: Medical/biological study (experimental study)

The effects of 50 Hz magnetic field exposure on dimethylbenz(alpha)anthracene induced thymic lymphoma/leukemia in mice med./bio.

By: Shen YH, Shao BJ, Chiang H, Fu YD, Yu M
Published in: Bioelectromagnetics 1997; 18 (5): 360-364
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Aim of study (acc. to author)

To investigate the effects of magnetic field exposure on the development of lymphoma and leukemia in DMBA treated mice.

Background/further details

Newborn mice were treated with a single dose of the chemical carcinogen DMBA (35 µg, subcutaneously injection) to initiate tumor development. Two weeks later MF-exposure (50 Hz, 1 mT, 3 h/day, 6 days/week, for 16 weeks) was started. Animals were sacrificed for examination at an age of 32 weeks. A DMBA treated but sham exposed group served as control.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 3 h/day, 6 days/week for 16 weeks

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration 3 h/day, 6 days/week for 16 weeks
Exposure setup
Exposure source
Setup 3 pairs of Helmholtz coils
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1 mT - measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The incidences of lymphoma and leukemia did not differ between MF-exposed and DMBA treated mice and sham-exposed mice also treated with DMBA. However, the metastatic infiltration by lymphoma cells into the liver was significantly increased (50%) in the MF/DMBA group.

Study character:

Study funded by

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