This in vivo study was performed to investigate the influence of 60 Hz magnetic fields on lymphoma induction in two strains of mice that are genetically predisposed to this disease.
Two transgenic mice model systems were used: 1.) pim-1 oncogene carrying mice (so called PIM transgenic mice, develop rapidly lymphoblastic lymphoma after a single dose of ethylnitrosourea) and 2.) mice which do not possess the tumor suppressor gene p53 (so called TSG-p53 mice).
Experiments were performed with 30 animals per sex and group to continuous and intermittent magnetic field exposure at different magnetic flux densities.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
60 Hz
Exposure duration:
18.5 h/day for 23 weeks
|
|
|
Exposure 2:
60 Hz
Exposure duration:
1 h on - 1 h off for 18.5 h/day for 23 weeks
|
|
| Frequency | 60 Hz |
|---|---|
| Type | |
| Polarization | |
| Exposure duration | 18.5 h/day for 23 weeks |
| Exposure source |
|
|---|---|
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 1 mT | maximum | measured | - | - |
| magnetic flux density | 0.2 mT | - | measured | - | - |
| magnetic flux density | 0.002 mT | minimum | measured | - | - |
| Frequency | 60 Hz |
|---|---|
| Type | |
| Polarization | |
| Exposure duration | 1 h on - 1 h off for 18.5 h/day for 23 weeks |
| Exposure source |
|
|---|---|
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 1 mT | - | measured | - | - |
The lymphoma incidence in male PIM mice exposed continuously to 10 G magnetic fields was significantly reduced from that seen in sex-matched sham exposure. No significant difference in the lymphoma incidence was observed between the sham exposure and the other exposure groups in both mice strains.
These results do not support the hypothesis that the exposure to magnetic fields is a significant risk factor for lymphoid neoplasia in mice with a genetic predisposition to this disease.
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