To study the effects of temperature elevation induced by a short-wave therapy device on early pregnancy of rats.
749 pregnant rats were exposed to a single short wave treatment in the first 16 days of the pregnancy inducing short lasting rectal temperatures of 42°C. Additional investigations were performed at 39 and 41°C and controls were performed at 38°C. On the 20th day of pregnancy 7800 foetuses were delivered by Caesarian section.
Exposure duration: continuous for approx. 10 min. (rectal temperatures of 42°C) at different days of early pregnancy
|Exposure duration||continuous for approx. 10 min. (rectal temperatures of 42°C) at different days of early pregnancy|
|Setup||abdomen of pregnant rats were heated by short-wave therapy apparatus|
No parameters are specified for this exposure.
As a consequence of the hyperthermia treatment numerous malformations arose. The data revealed malformations of the central nervous system, the eys, the tail and extremities as well as cleft palates. The malformation type corresponded to the teratogenic phase at the time of the short wave treatment. Before implantation (i.e. during the first days of pregnancy), the short-wave therapy was lethal for the majority of the embryos.