Study type: Medical/biological study (experimental study)

The effect of extremely low frequency magnetic field on the conjunctiva and goblet cells. med./bio.

Published in: Curr Eye Res 2008; 33 (5): 441-446

Aim of study (acc. to author)

The aim of this study was to examine the effects of extremely low frequency 1.5 mT magnetic field on the ocular conjunctiva in rats.

Background/further details

Goblet cells' function is to secrete mucus.
Thirty adult female rats (weighing 250-300 g) were assigned to exposure group and cage control, each containing 15 animals. Exposures were performed on animals which were not in estrous cycle.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuous for 4 h/day for 7 days

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration continuous for 4 h/day for 7 days
Exposure setup
Exposure source
Setup two pairs of Helmholtz coils with a diameter of 70 cm each, separated by 47 cm; placed inside a Faraday cage
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1.5 mT - measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

In exposed rats, the number of goblet cells was less than the control group. Additionally, a significant decrease in goblet cell density was observed, accompanied by conjunctival edema and inflammation. Concerning fibroblast proliferation, an increase, but not statistical significant, was found in exposed rats.
These results suggest that the exposure to 50 Hz, 1.5 mT extremely low frequency magnetic field leads to morphological alterations of the conjunctiva which may cause dry eye symptoms.

Study character:

Study funded by

Related articles