Study type: Medical/biological study (experimental study)

Absence of effect of power-frequency magnetic fields exposure on mouse embryonic lens development. med./bio.

Published in: Bioelectromagnetics 2007; 28 (8): 628-635

Aim of study (acc. to author)

To study whether power frequency magnetic fields induce changes in morphology or protein and/or transcription factor levels (of developmentally regulated transcription factors) in developing mouse embryonic eye lenses.

Background/further details

Three groups of pregnant mice were exposed to magnetic fields of varying intensities from gestation day 0 to 18. The embryonic eye lenses were enucleated on gestation day 18.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 3 h/day for 18 days (from day 0 to 18 of gestation)

General information

mice were treated in three groups: i) exposure to 1.5 mT ii) exposure to 4.5 mT iii) sham exposure

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration 3 h/day for 18 days (from day 0 to 18 of gestation)
Exposure setup
Exposure source
Setup pair of Helmholtz coils with 123 turns of 10 mm² copper wire and a radius of 0.25 m each; pregnant mice placed in 4.5 cm x 4.5 cm x 9 cm plastic cages in the center of a 50 cm x 80 cm wooden board between the coils
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1.5 mT - measured - -
magnetic flux density 4.5 mT - measured - -
electric field strength 27.1 V/m - measured - -
electric field strength 88.5 V/m - measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

No effects of 50 Hz magnetic field exposure with intensities of up to 4.5 mT on eye lens development in embryonic mice were detected.
No significant differences were found in eye lens transparency, and the lens epithelial cells from the experimental groups exhibited normal ultrastructure comparable to the control. Furthermore, no significant differences were found among the protein contents and the mRNA expression levels of the transcription factors.

Study character:

Study funded by

Related articles