Study type: Medical/biological study (experimental study)

Evaluation of the potential in vitro antiproliferative effects of millimeter waves at some therapeutic frequencies on RPMI 7932 human skin malignant melanoma cells. med./bio.

Published in: Cell Biochem Biophys 2009; 55 (1): 25-32

Aim of study (acc. to author)

To evaluate the potential effects of millimeter waves on cell proliferation and cell cycle of human melanoma cells at two different frequencies (42.20 GHz and 53.57 GHz).

Background/further details

These two frequencies are used in millimeter wave therapy applications.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 42.2 GHz
Modulation type: CW
Exposure duration: continuous for 1 h/day on 4 days
Exposure 2: 53.57 GHz
Modulation type: CW
Exposure duration: continuous for 1 h/day on 4 days

Exposure 1

Main characteristics
Frequency 42.2 GHz
Type
Charakteristic
Polarization
Exposure duration continuous for 1 h/day on 4 days
Additional info +/- 0.05 GHz
Modulation
Modulation type CW
Exposure setup
Exposure source
Distance between exposed object and exposure source 39 cm
Setup conical horn antenna with a diameter of 34 mm placed under the multiwell plates inside an incubator
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
power 24 mW - - - output power
power density 0.11 mW/cm² - - - in the samples

Exposure 2

Main characteristics
Frequency 53.57 GHz
Type
Charakteristic
Polarization
Exposure duration continuous for 1 h/day on 4 days
Additional info +/- 0.05 GHz
Modulation
Modulation type CW
Exposure setup
Exposure source
Distance between exposed object and exposure source 39 cm
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
power 39 mW - - - output power
power density 0.26 mW/cm² - - - in the samples

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The data showed that non-thermal millimeter wave exposures at 42.20 and 53.57 GHz do not affect the proliferation rate or the cell cycle of RPMI 7932 melanoma cells.

Study character:

Study funded by

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