Medical/biological study (experimental study)

Effects of 50 Hertz-1 mT magnetic field on action potential in isolated rat sciatic nerve med./bio.

By: Coskun O, Naziroglu M, Comlekci S, Ozkorucuklu S

Published in: Toxicol Ind Health 2011; 27 (2): 127-132

Aim of study (acc. to author)

To study the possible effects of a 50 Hz magnetic field on action potential in isolated rat sciatic nerve.

Background/further details

16 rats were divided into a control group (n = 10) and a magnetic field exposure group (n = 6). The sciatic nerves of left legs were excised and exposed to the magnetic field for 30 minutes.

Endpoint

cell function: action potential in the isolated sciatic nerve

Exposure

- 50/60 Hz
- magnetic field

Exposure	Parameters
Exposure 1: 50 Hz Exposure duration: continuous for 30 min	magnetic flux density: 1 mT

Exposure 1

Main characteristics

Frequency	50 Hz
Type	magnetic field
Waveform	sinusoidal
Exposure duration	continuous for 30 min

Exposure setup

Exposure source	Helmholtz coils
Setup	pair of Helmholtz coils with a diameter of 10 cm and 220 turns of 0.8 mm gauge copper wire each; coils mounted on a plastic frame, 15 cm apart, parallel to the table, connected in series
Sham exposure	A sham exposure was conducted.
Additional info	isolated sciatic nerve fibers of the control group were located in bath and stimulated with 0.1- 0.5 ms, 0.05 V pulse

Parameters

Measurand	Value	Type	Method	Mass	Remarks
magnetic flux density	1 mT	-	measured and calculated	-	-

Exposed system:

isolated sciatic nerve

Methods Endpoint/measurement parameters/methodology

cell function: action potential in the isolated sciatic nerve (conduction duration, maximum and minimum amplitude, durations of depolarization, repolarization and hyperpolarization)

Investigated system:

isolated sciatic nerve

Time of investigation:

during exposure

Main outcome of study (acc. to author)

The data showed that maximum amplitude and hyperpolarization time were significantly lower in the magnetic field exposure group than in the control group. However, conduction time, minimum amplitude, depolarization and repolarization times of the action potential were not different between control group and magnetic field group.
In conclusion, the 50 Hz magnetic field exposure caused a decrease in the maximum amplitude value and hyperpolarization time of the action potential in the rat nerve.

Study character:

medical/biological study
experimental study
full/main study

Study funded by

not stated/no funding

Saito A et al. (2018): Response of Cultured Neuronal Network Activity After High-Intensity Power Frequency Magnetic Field Exposure
Elmas O et al. (2015): Investigation of effects of short-term exposure to 50 HZ magnetic field on central, peripheral, and autonomic nervous systems in rats
Comlekci S et al. (2012): Influence of 50 Hz-1 mT magnetic field on human median nerve
Gunay I et al. (2011): Pulsed magnetic fields enhance the rate of recovery of damaged nerve excitability
Novikov SM et al. (2008): Influence of weakened constant magnetic field on nerve cell excitability
Olree KS et al. (2006): Differential activation and block of peripheral nerve fibers by magnetic fields
Marchionni I et al. (2006): Comparison between low-level 50 Hz and 900 MHz electromagnetic stimulation on single channel ionic currents and on firing frequency in dorsal root ganglion isolated neurons
Bailey WH et al. (2005): Thresholds for 60 Hz magnetic field stimulation of peripheral nerves in human subjects

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