Study type: Medical/biological study (experimental study)

Effects of 50 Hertz-1 mT magnetic field on action potential in isolated rat sciatic nerve. med./bio.

Published in: Toxicol Ind Health 2011; 27 (2): 127-132

Aim of study (acc. to author)

To study the possible effects of a 50 Hz magnetic field on action potential in isolated rat sciatic nerve.

Background/further details

16 rats were divided into a control group (n = 10) and a magnetic field exposure group (n = 6). The sciatic nerves of left legs were excised and exposed to the magnetic field for 30 minutes.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuous for 30 min

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration continuous for 30 min
Exposure setup
Exposure source
Setup pair of Helmholtz coils with a diameter of 10 cm and 220 turns of 0.8 mm gauge copper wire each; coils mounted on a plastic frame, 15 cm apart, parallel to the table, connected in series
Sham exposure A sham exposure was conducted.
Additional info isolated sciatic nerve fibers of the control group were located in bath and stimulated with 0.1- 0.5 ms, 0.05 V pulse
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1 mT - measured and calculated - -

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • during exposure

Main outcome of study (acc. to author)

The data showed that maximum amplitude and hyperpolarization time were significantly lower in the magnetic field exposure group than in the control group. However, conduction time, minimum amplitude, depolarization and repolarization times of the action potential were not different between control group and magnetic field group.
In conclusion, the 50 Hz magnetic field exposure caused a decrease in the maximum amplitude value and hyperpolarization time of the action potential in the rat nerve.

Study character:

Study funded by

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