Study type: Medical/biological study (experimental study)

Extremely Low Frequency Electromagnetic Fields Facilitate Vesicle Endocytosis by Increasing Presynaptic Calcium Channel Expression at a Central Synapse med./bio.

Published in: Sci Rep 2016; 6: 21774

Aim of study (acc. to author)

The effects of exposure of young mice to a 50 Hz magnetic field on synaptic transmission and synaptic plasticity in the brain should be investigated.

Background/further details

Investigations were conducted at the Calyx of Held, a particularly large synapse in the mammalian brain.
Exposure started on the day of birth.



Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuous for 8 to 10 days

Exposure 1

Main characteristics
Frequency 50 Hz
Exposure duration continuous for 8 to 10 days
Exposure setup
Exposure source
Measurand Value Type Method Mass Remarks
magnetic flux density 1 mT - measured - -

Reference articles

  • He YL et al. (2013): Exposure to Extremely Low-Frequency Electromagnetic Fields Modulates Na(+) Currents in Rat Cerebellar Granule Cells through Increase of AA/PGE(2) and EP Receptor-Mediated cAMP/PKA Pathway

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Compared to the control group, exposure to the magnetic field significantly increased the calcium influx upon electrical stimulation and all forms of vesicle endocytosis. However, exposure did not affect the size of the readily releasable pool or exocytosis.
Exposure to the magnetic field also significantly increased the amplitude of post-tetanic potentiation compared to the control group without influencing its time course.
Investigating the underlying mechanisms of action, a significantly increased protein expression and gene expression of P/Q and N subtype calcium ion channels was found in exposed samples compared to the control group. The increased calcium influx upon stimulation in exposed samples might have been realized via these channels.
The authors conclude, that exposure of young mice to a 50 Hz magnetic field might increase vesicle endocytosis and synaptic plasticity in a calcium-dependent manner by increasing calcium ion channel expression at nerve terminals in the brain.
(remark EMF-Portal: group sizes unclear)

Study character:

Study funded by

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