研究のタイプ: 医学/生物学の研究 (experimental study)

[超低周波電磁界は中枢シナプスのシナプス前カルシウムチャネル発現を増加させて小胞エンドサイトーシスを促進する] med./bio.

Extremely Low Frequency Electromagnetic Fields Facilitate Vesicle Endocytosis by Increasing Presynaptic Calcium Channel Expression at a Central Synapse

掲載誌: Sci Rep 2016; 6: 21774

この研究は、超低周波電磁界(ELF-EMF)へ8−10日間ばく露した哺乳類中枢神経系の巨大シナプス終末(calyx of Held)でのカルシウム電流および膜容量を測定した。その結果、ばく露は、神経終末でのカルシウムチャネル発現を増加させ、カルシウム依存的に小胞エンドサイトーシスおよびシナプス可塑性促進することが示された、と報告している。

The detailed summary of this article is not available in your language or incomplete. Would you like to see a complete translation of the summary? Then please contact us →

研究目的(著者による)

The effects of exposure of young mice to a 50 Hz magnetic field on synaptic transmission and synaptic plasticity in the brain should be investigated.

詳細情報

Investigations were conducted at the Calyx of Held, a particularly large synapse in the mammalian brain.
Exposure started on the day of birth.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: continuous for 8 to 10 days

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
ばく露時間 continuous for 8 to 10 days
ばく露装置
ばく露の発生源/構造
パラメータ
測定量 種別 Method Mass 備考
磁束密度 1 mT - 測定値 - -

Reference articles

  • He YL et al. (2013): [超低周波電磁界へのばく露はAA/PGE2経路およびEP受容体介在性cAMP/PKA経路の生成レベル上昇によりラット小脳顆粒細胞のナトリウムイオン電流を変化させる]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Compared to the control group, exposure to the magnetic field significantly increased the calcium influx upon electrical stimulation and all forms of vesicle endocytosis. However, exposure did not affect the size of the readily releasable pool or exocytosis.
Exposure to the magnetic field also significantly increased the amplitude of post-tetanic potentiation compared to the control group without influencing its time course.
Investigating the underlying mechanisms of action, a significantly increased protein expression and gene expression of P/Q and N subtype calcium ion channels was found in exposed samples compared to the control group. The increased calcium influx upon stimulation in exposed samples might have been realized via these channels.
The authors conclude, that exposure of young mice to a 50 Hz magnetic field might increase vesicle endocytosis and synaptic plasticity in a calcium-dependent manner by increasing calcium ion channel expression at nerve terminals in the brain.
(remark EMF-Portal: group sizes unclear)

研究の種別:

研究助成

関連論文