Study type: Medical/biological study (experimental study)

Alterations in ornithine decarboxylase activity in the rat mammary gland after different periods of 50 Hz magnetic field exposure. med./bio.

Published in: Bioelectromagnetics 1999; 20 (6): 338-346

Aim of study (acc. to author)

To investigate the effects of 50 Hz magnetic field (MF) exposure of different time periods on the ornithine decarboxylase (ODC) activity in rat mammary gland. Furthermore the ornithine decarboxylase activity was determined in different mammary complexes of the rat mammary organ.

Background/further details

Rats were exposed/sham-exposed up to 13 weeks in several experiments. Examination were done at 1 day of exposure and after 2, 8, and 13 weeks, respectively. Variable numbers of animals were examined at these time points (i.e. group ranges between 6-18 animals). A positive control was conducted after approximately 65 days of exposure using the chemical tumor promotor TPA.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 24 h/day, 7days/week, up to 13 weeks

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration 24 h/day, 7days/week, up to 13 weeks
Additional info horizontal
Exposure setup
Exposure source
  • not specified
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 100 µT - measured - -

Reference articles

  • Baum A et al. (1995): A histopathological study on alterations in DMBA-induced mammary carcinogenesis in rats with 50 Hz, 100 muT magnetic field exposure.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
  • breast
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

The main finding of this study is that 50 Hz 100 µT MF exposure of young female rats for two weeks induces a reproducible increase in ornithine decarboxylase activity. No changes in ODC activity were found for short term exposure (< 1 week) and long term exposure (> 8 weeks).
Furthermore, the increased ODC activity, observed after two weeks of exposure, was mainly located in in the thoracic, particularly in the cranial thoracic part of the mammary gland.

Study character:

Study funded by

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