To investigate the effects of 50 Hz magnetic field (MF) exposure of different time periods on the ornithine decarboxylase (ODC) activity in rat mammary gland. Furthermore the ornithine decarboxylase activity was determined in different mammary complexes of the rat mammary organ.
Rats were exposed/sham-exposed up to 13 weeks in several experiments. Examination were done at 1 day of exposure and after 2, 8, and 13 weeks, respectively. Variable numbers of animals were examined at these time points (i.e. group ranges between 6-18 animals). A positive control was conducted after approximately 65 days of exposure using the chemical tumor promotor TPA.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
50 Hz
Exposure duration:
24 h/day, 7days/week, up to 13 weeks
|
|
| Frequency | 50 Hz |
|---|---|
| Type | |
| Exposure duration | 24 h/day, 7days/week, up to 13 weeks |
| Additional info | horizontal |
| Exposure source |
|
|---|---|
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 100 µT | - | measured | - | - |
The main finding of this study is that 50 Hz 100 µT MF exposure of young female rats for two weeks induces a reproducible increase in ornithine decarboxylase activity. No changes in ODC activity were found for short term exposure (< 1 week) and long term exposure (> 8 weeks).
Furthermore, the increased ODC activity, observed after two weeks of exposure, was mainly located in in the thoracic, particularly in the cranial thoracic part of the mammary gland.
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