To study the effects of prolonged exposure to low-intensity microwave fields on heat shock (HSP) responses in transgenic Caenorhabditis elegans.
Modulation type: CW
Exposure duration: continuous for 18 h
|Exposure duration||continuous for 18 h|
|Chamber||Incubator temperatures of 24.0, 24.5, 25.0 and 25.5 °C were tested using 12 replicates for each condition. Controls (6 replicates) were also run at 22, 26, 27 and 28 °C.|
|Additional info||Temperature control worm cultures were shielded with aluminium foil and placed in the same incubator. Baseline controls were maintained at 15°C.|
|electric field strength||45 V/m||-||-||-||at the center of the TEM cell|
It is shown that prolonged exposure to low-intensity microwave fields can induce heat shock protein responses. In exposed cultures, expression is comparable to that of controls at 24°C, but then it rises steeply.
It is suggested that the induction of heat shock proteins described here could involve non-thermal mechanisms. These could include microwave disruption of the weak bonds that maintain the active folded forms of proteins, enhanced production of reactive oxygen species (ROS), or interference with cell-signalling pathways that affect HSP induction.