Study type: Medical/biological study (experimental study)

Transgenic nematodes as biomonitors of microwave-induced stress. med./bio.

Published in: Mutation Research - Fundamental and Molecular Mechanism of Mutagenesis 1998; 399 (1): 55-64

Aim of study (acc. to editor)

To demonstrate microwave-induced stress responses in transgenic Caenorhabditis elegans (i.e. nematodes) which are both reproducible and simple to detect. The effects of continuous microwave radiation on heat-shock protein (HSP) responses were investigated.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 750 MHz
Exposure duration: continuous for 2, 4, 8 or 16 h
-
Exposure 2: 300–750 MHz
Exposure duration: continuous for 16 h
-

Exposure 1

Main characteristics
Frequency 750 MHz
Type
Exposure duration continuous for 2, 4, 8 or 16 h
Exposure setup
Exposure source
  • TEM cell
  • 34 cm long, 24 x 24 cm at the center, 1.5 x 1.5 cm at the ends
Chamber TEM cell placed in an incubator at 25°C in a shielded room
Setup worms placed centrally in the TEM cell
Sham exposure A sham exposure was conducted.
Parameters

No parameters are specified for this exposure.

Exposure 2

Main characteristics
Frequency 300–750 MHz
Type
Exposure duration continuous for 16 h
Additional info experiments dane at 300 MHz and 750 MHz
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters

No parameters are specified for this exposure.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The data suggest that microwave radiation causes measurable stress to transgenic nematodes. 750 MHz irradiation of nematodes caused stress reporter gene induction after 2 and 16 hours but not after 4 and 8 hours of exposure.
Exposure to 750 MHz but not to 300 MHz at different power settings (500, 250, 125 mW) for 16 hours caused stress reporter gene induction in nematodes. The results are reproducible and data acquisation is both rapid and simple.

Study character:

Study funded by

Replication studies

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