研究のタイプ: 医学／生物学の研究 (experimental study)

[マイクロ波による非熱的熱ショック応答] retracted

Non-thermal heat-shock response to microwaves (RETRACTED)

著者: de Pomerai D, Daniells C, David H, Allan J, Duce I, Mutwakil M, Thomas D, Sewell P, Tattersall J, Jones D, Candido P
掲載誌: Nature 2000; 405 (6785): 417-418
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研究目的(acc. to editor)

To study the effects of prolonged exposure to low-intensity microwave fields on heat shock (HSP) responses in transgenic Caenorhabditis elegans.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 750 MHz
Modulation type: CW
ばく露時間: continuous for 18 h

ばく露1

主たる特性
周波数 750 MHz
タイプ
  • electromagnetic field
特性
  • guided field
ばく露時間 continuous for 18 h
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
チャンバの詳細 Incubator temperatures of 24.0, 24.5, 25.0 and 25.5 °C were tested using 12 replicates for each condition. Controls (6 replicates) were also run at 22, 26, 27 and 28 °C.
Additional information Temperature control worm cultures were shielded with aluminium foil and placed in the same incubator. Baseline controls were maintained at 15°C.
パラメータ
測定量 値 種別 Method Mass 備考
電力 0.5 W - - - -
電界強度 45 V/m - - - at the center of the TEM cell
SAR 0.001 W/kg - 計算値 - -

Reference articles

  • Daniells C et al. (1998): [マイクロ波によって誘起されるストレスのバイオモニターとしてのトランスジェニック線虫]

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:

研究の主なアウトカム（著者による）

It is shown that prolonged exposure to low-intensity microwave fields can induce heat shock protein responses. In exposed cultures, expression is comparable to that of controls at 24°C, but then it rises steeply.
It is suggested that the induction of heat shock proteins described here could involve non-thermal mechanisms. These could include microwave disruption of the weak bonds that maintain the active folded forms of proteins, enhanced production of reactive oxygen species (ROS), or interference with cell-signalling pathways that affect HSP induction.

研究の種別:

研究助成

Replication studies

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