Study type: Medical/biological study (experimental study)

Circulatory failure induced by 35 GHz microwave heating: effects of chronic nitric oxide synthesis inhibition med./bio.

By: Ryan KL, Frei MR, Jauchem JR
Published in: Shock 1997; 7 (1): 70-76
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Aim of study (acc. to author)

To explore the contribution of NO in producing millimter wave-induced hypotension by administering L-NAME (N omega-nitro-L-arginine methyl ester, a NO synthesis inhibitor) before exposure.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 35 GHz
Modulation type: CW
Exposure duration: until blood pressure fell to 75mmHg
  • SAR: 13 mW/g mean (whole body) (determined calorimetrically.)
  • power density: 750 W/m² unspecified

Exposure 1

Main characteristics
Frequency 35 GHz
Type
Charakteristic
Polarization
Exposure duration until blood pressure fell to 75mmHg
Modulation
Modulation type CW
Exposure setup
Exposure source
Distance between exposed object and exposure source 1.1 m
Chamber RF-shielded anechoic chamber (27°C, 20% humidity), holder
Setup The animal was placed on a Plexiglass holder (centered along the boresight) and exposed in an E-orientation
Parameters
Measurand Value Type Method Mass Remarks
SAR 13 mW/g mean calculated whole body determined calorimetrically.
power density 750 W/m² unspecified measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • before exposure
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

NO synthesis inhibition produced by chronic L-NAME administration before microwave heating does not protect ketamine-anesthetized rats from this form of lethal heat stress. These results (taken together with previous results) indicate that increased levels of NO do not mediate the hypotensive state produced by this mode of hyperthermia.

Study character:

Study funded by

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