To examine effects of tolazoline (10 mg/kg body weight) on heart rate, mean arterial blood pressure, respiratory rate, localized body temperature changes, survival times, and lethal body temperatures that occur during exposure of anesthetized rats to 2450 MHz microwave radiation.
Survival time was significantly shorter in the tolazoline group than in saline-treated control animals. Heart rate and blood pressure responses were similar to those that occur during environmental heat stress. Heart rate, however, was significantly elevated in animals that received tolazoline. It is possible that changes associated with the elevated heart rate in tolazoline-treated animals resulted in greater susceptibility to microwave-induced heating and the lower survival time.