To investigate the effects of a 60 Hz magnetic field exposure on progression of leukemia in the LGL-rat model. The LGL (large granular lymphocytic) leukemia model is used to induce leukemia in young, male rats within a relatively short period of time by engrafting spleen cells from aged leukemic rats. Main objectives were: a) to replicate a previous study, using a lower number of intraperitoneally injected LGL leukemic spleen cells (i.e. 2.2x106 instead of 2.2x107 cells), and b) to determine if effects of an intermitted 60 Hz magnetic field (3 min on/off interval) are distinguishable from those of a continuous magnetic field exposure.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
60 Hz
Exposure duration:
repeated daily exposure, 20h/day, 7days/week for 16 weeks
|
|
|
Exposure 2:
60 Hz
Exposure duration:
intermittent, 3 min on/off, 20 h/day, 7days/week for 16 weeks
intermittend (3 min on/off interval)
|
|
| Frequency | 60 Hz |
|---|---|
| Type | |
| Waveform | |
| Polarization | |
| Exposure duration | repeated daily exposure, 20h/day, 7days/week for 16 weeks |
| Exposure source |
|
|---|---|
| Chamber | polyethylen cages |
| Additional info | The exposure system consisted of four units with six 1.05 x 3.6 m cage support shelves spaced 30 cm apart. Within each unit, the shelves are arranged vertically into two groups of three, with each group surrounded by coils. Each exposure system had four tiers for holding rat cages with each tier accommodating four polycarbonate modules of six individual rat cages on each side. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 1 mT | mean | measured | - | - |
| Frequency | 60 Hz |
|---|---|
| Type | |
| Waveform | |
| Polarization | |
| Exposure duration | intermittent, 3 min on/off, 20 h/day, 7days/week for 16 weeks |
| Additional info | intermittend (3 min on/off interval) |
| Exposure source |
|
|---|
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 1 mT | mean | measured | - | - |
A total of 72 animal (divided into 4 groups, 18 animals each) were used in this study. No significant differences in either survival time or body weight could be found between the exposed and the unexposed animal. Furthermore, no consistant differences on hematological pattern could be demonstrated between continuously or intermittently exposed rats.
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