Study type: Medical/biological study (experimental study)

Cell membrane permeabilization of human erythrocytes by athermal 2450-MHz microwave radiation. med./bio.

Published in: IEEE Trans Microw Theory Tech 2000; 48 (11): 2072-2075

Aim of study (acc. to author)

To study the effects of long-term exposure of human blood to 2.45 GHz continuous wave irradiation at athermal power densities.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: CW
Exposure duration: 60 h (84 h kinetic measurements)

Exposure 1

Main characteristics
Frequency 2.45 GHz
Type
Exposure duration 60 h (84 h kinetic measurements)
Modulation
Modulation type CW
Exposure setup
Exposure source
Setup 72 mm x 34 mm x 8 mm polystyrene block with 10 holes of 5 mm diameter and 32 mm depth inside the waveguide system; samples placed in the block's holes
Parameters
Measurand Value Type Method Mass Remarks
power density 0.025 mW/cm² minimum measured - -
power density 10 mW/cm² maximum measured - -

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

A significant increase of the hemoglobin loss by irradiated erythrocytes as well as a strong dependence of the rate of the increase of hemoglobin loss on the initial level of spontaneous hemolysis were revealed. It was found that at low power densities, the hemolysis degree increases quasi-linearily with the exposure time, while at higher power density (5 mW/cm²), this tendency is reversed after first 10 h of irradiation. Long-term irradiation seems to exert a protective effect against spontaneous hemolysis caused by blood ageing. The osmotic fragility test performed on samples exposed to 5 mW/cm² at different irradiation times showed that the osmotic resistance increased in time, reaching a maximum at the end of irradiation (60 h), while the osmotic resistance of the controls was constant.

Study character:

Study funded by

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