Study type: Medical/biological study (experimental study)

Multinucleated giant cell appearance after whole body microwave irradiation of rats. med./bio.

Published in: Int J Hyg Environ Health 2001; 204 (2-3): 133-138

Aim of study (acc. to author)

To gather information about the influence of selected electromagnetic radiation on the kinetics of alveolar macrophages and the formation of multinucleated giant cells after whole body microwave irradiation of rats.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Exposure duration: 2 hrs per day, 5 days a week for 30 days (animals killed on experimental days 1, 8, 16, 30)

Exposure 1

Main characteristics
Frequency 2.45 GHz
Type
Exposure duration 2 hrs per day, 5 days a week for 30 days (animals killed on experimental days 1, 8, 16, 30)
Exposure setup
Exposure source
  • not specified
Chamber Plexiglass cages
Parameters
Measurand Value Type Method Mass Remarks
power density 50 W/m² minimum unspecified - corresponding SAR ca. 20 mW/g
power density 150 W/m² maximum unspecified - corresponding SAR ca. 20 mW/g

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Total cell number slightly decreased in treated animals showing time- and dose-dependance. Cell viability did not significantly change in the irradiated animal group. Binucleation and multinucleation of alveolar macrophages were sensitive time- and dose-dependent morphological indicators of pulmonary stress.

Study character:

Study funded by