To study whether electromagnetic field exposure was able to modulate ETS1 and ETS2 oncogene expression in spleen tissue of mice. ETS1 and ETS2 are members of a family of transcription factors involved in cell differentiation, tumorigenesis, and apoptosis.
Exposure | Parameters |
---|---|
Exposure 1:
50 MHz
Modulation type:
AM
Exposure duration:
1-20 h.
|
|
Male mice were randomly divided into control, sham and exposed groups.
Frequency | 50 MHz |
---|---|
Charakteristic |
|
Exposure duration | 1-20 h. |
Modulation type | AM |
---|---|
Modulation frequency | 16 Hz |
Modulation depth | 80 % |
Measurand | Value | Type | Method | Mass | Remarks |
---|---|---|---|---|---|
electric field strength | 60 V/m | - | cf. remarks | - | MF: 0.2 µT. |
An increase in ETS1 mRNA and protein expression, but a decrease in ETS2 protein levels was observed. Preliminary data from this experimental model show in vivo evidence of the effect of electromagnetic field on ETS oncogene expression.
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