Study type: Medical/biological study (experimental study)

In vivo modulation of ETS genes induced by electromagnetic fields med./bio.

By: Mucci N, Ianni A, Ursini CL, Arzani D, Bhat NK, Navarra P, Romano-Spica V
Published in: In Vivo 2001; 15 (3): 489-494
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Aim of study (acc. to author)

To study whether electromagnetic field exposure was able to modulate ETS1 and ETS2 oncogene expression in spleen tissue of mice. ETS1 and ETS2 are members of a family of transcription factors involved in cell differentiation, tumorigenesis, and apoptosis.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 MHz
Modulation type: AM
Exposure duration: 1-20 h.

General information

Male mice were randomly divided into control, sham and exposed groups.

Exposure 1

Main characteristics
Frequency 50 MHz
Charakteristic
  • guided field
Exposure duration 1-20 h.
Modulation
Modulation type AM
Modulation frequency 16 Hz
Modulation depth 80 %
Exposure setup
Exposure source
Setup Mice were housed in plastic cages (180 x 180 x 100 mm³) placed on the septum of each TEM cell.
Additional info exposed and control unexposed trails were conducted simultaneously in different tTEM cells.
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 60 V/m - cf. remarks - MF: 0.2 µT.
Additional parameter details

Geomagnetic field inside the TEM cell was measured to be 46 µT at an inclination of 60°.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

An increase in ETS1 mRNA and protein expression, but a decrease in ETS2 protein levels was observed. Preliminary data from this experimental model show in vivo evidence of the effect of electromagnetic field on ETS oncogene expression.

Study character:

Study funded by

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