Study type: Medical/biological study (observational study)

X-rays, microwaves and vinyl chloride monomer: their clastogenic and aneugenic activity, using the micronucleus assay on human lymphocytes med./bio.

Published in: Mutation Research - Letters 1992; 282 (4): 265-271

Aim of study (acc. to author)

In order to distinguish clastogenic from aneugenic activity of mutagens, the micronucleus test was used. Cytochalasin cytokinesis-blocked human lymphocytes from populations that had been occupationally exposed to three well-known mutagenic agents were analysed: vinyl chloride, ionizing and microwave radiation.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 1.25–1.35 GHz
Modulation type: pulsed
Exposure 2: -
Exposure 3: -

Exposure 1

Main characteristics
Frequency 1.25–1.35 GHz
Type
Waveform
Modulation
Modulation type pulsed
Exposure setup
Exposure source
  • not specified
Additional info People who were occupationally exposed to MW, X-rays or vinyl chloride monomer.
Parameters
Measurand Value Type Method Mass Remarks
power density 10 µW/cm² unspecified measured - 20 mW/cm²; at the working place of the subject.

Exposure 2

Main characteristics
Type
Waveform
Additional info frequency: 100 PHz
Exposure setup
Exposure source
  • not specified
Parameters

No parameters are specified for this exposure.

Exposure 3

Main characteristics
Exposure setup
Parameters

No parameters are specified for this exposure.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The comparison of frequencies of size distribution of micronuclei in the lymphocytes of subjects exposed to each of the three mutagens showed that X-rays and microwaves were preferentially clastogens while vinyl chloride monomer showed aneugenic activity as well. Microwaves possess some mutagenic characteristics typical of chemical mutagens.

Study character:

Study funded by

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