Study type: Medical/biological study (experimental study)

Effects of 900-MHz Microwave Radiation on gamma-Ray-Induced Damage to Mouse Hematopoietic System. med./bio.

Published in: J Toxicol Environ Health A 2010; 73 (7): 507-513

Aim of study (acc. to author)

To study the effects of microwave exposure on hematopoietic damage induced by ionizing radiation.

Background/further details

In a previous study (Meng et al. 2007) it was shown that low-dose microwave exposure increased the survival rate of mice irradiated with 8-Gy gamma rays. However, the underlying mechanisms remained unknown.
96 mice were divided into four groups: 1) control group, 2) microwave exposure group, 3) gamma rays (5 Gy) exposure group, and 4) co-exposure group (microwave + gamma rays). Mice were sacrificed 3, 6, 9, or 12 days (six mice each day of each group) after the gamma ray exposure.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Exposure duration: continuous for 1 h/day on 14 days

General information

mice were treated in four groups: i) control ii) microwave irradiation iii) gamma-ray irradiation (5 Gy) on day 15 iv) microwave irradiation + gamma-ray irradiation on day 15

Exposure 1

Main characteristics
Frequency 900 MHz
Type
Exposure duration continuous for 1 h/day on 14 days
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
power density 120 µW/cm² - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The data showed that pre-exposure to low-dose microwaves attenuated hematopoietic injuries produced by subsequent gamma radiation. The protective effects of microwave exposure appeared to be related to 1) up-regulation of some hematopoietic growth factors, 2) stimulation of proliferation of the granulocyte-macrophages in bone marrow, and 3) antagonism of the gamma ray-induced inhibition of hematopoietic stem cells/hematopoietic progenitor cells.

Study character:

Study funded by

Related articles