Study type: Medical/biological study (experimental study)

Effect of environmental temperature on the interactive developmental toxicity of radiofrequency radiation and 2-methoxyethanol in rats. med./bio.

Published in: Int Arch Occup Environ Health 1998; 71 (6): 413-423

Aim of study (acc. to author)

To study if altered environmental temperatures (18°C, 24°C, and 30°C) would affect the interactive developmental toxicity of radiofrequency irradiation and the industrial solvent, 2-methoxyethanol. This is important because radiofrequency irradiation is used in a variety of workplaces that have poorly controlled environmental temperatures, and many workers are concurrently exposed to chemicals.

Background/further details

Furthermore, the authors have previously demonstrated that combined exposure to radiofrequency irradiation (10 MHz) and 2-methoxyethanol produces enhanced teratogenicity in rats (publication 3519).
Radiofrequency irradiation sufficient to maintain colonic temperatures at the control value (38°C), 39°C or 40°C for 2 or 4 h combined with 2-methoxyethanol (0 or 100 mg/kg) at different environmental temperatures were given on gestation day 13 to rats. Dams were killed on gestation day 20, and the fetuses were examined for external malformations.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 10 MHz
Modulation type: CW
Exposure duration: 2 or 4 h
  • SAR: 8 mW/g minimum (unspecified) (set initially)
  • SAR: 800 µW/g minimum (unspecified) (7.9 W/kg)

Exposure 1

Main characteristics
Frequency 10 MHz
Type
Charakteristic
Exposure duration 2 or 4 h
Modulation
Modulation type CW
Exposure setup
Exposure source
  • not specified
Chamber near field synthesizers enclosed within copper wire chambers housed in Forma 7010 or 74668 environmental chambers.
Setup rats placed in cylinderical plexiglass holders with 12 mm holes
Additional info Each rat was oriented in its long axis for induced EF to be parallel. Rats irradiated in one of the two RF-near field synthesizer facilities designed by NIOSH.
Parameters
Measurand Value Type Method Mass Remarks
SAR 8 mW/g minimum - unspecified set initially
SAR 800 µW/g minimum - unspecified 7.9 W/kg

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

Environmental temperature does affect the specific absorption rate necessary to maintain a specific colonic temperature but does not affect the interactive developmental toxicity of radiofrequency irradiation and 2-methoxyethanol. These data add to the evidence that the developmental toxicity of radiofrequency irradiation (combined or alone) is associated with colonic temperature, not with SAR.

Study character:

Study funded by

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